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Radiation Therapy for Ovarian Cancer

Radiation therapy uses high energy x-rays or particles to kill cancer cells. Radiation therapy is not commonly used in the US as the main treatment for ovarian cancer. However, it can be useful in treating areas where the cancer has spread and is causing symptoms, like the brain or spinal cord.

External beam radiation therapy

The most common type of radiation therapy for women with ovarian cancer is external beam radiation therapy. It is much like getting an x-ray, but the radiation is stronger. A machine focuses the radiation on the area affected by the cancer. The procedure itself is painless. Each treatment lasts only a few minutes, but the setup time¡ªgetting you into place for treatment¡ªusually takes longer. Treatments are generally given 5 days a week for several weeks.

Common side effects include:

  • Skin changes ¨C the skin in the treated area may look and feel sunburned or even blister and peel
  • Fatigue (tiredness)
  • Nausea and vomiting
  • Diarrhea
  • Vaginal irritation, sometimes with a discharge (if the pelvis is being treated)

These side effects usually improve after treatment is stopped. Skin changes gradually fade, and the skin returns to normal in 6 to 12 months.

If you are having side effects from radiation, tell your cancer care team. There may be ways to manage them.

Brachytherapy

Brachytherapy, also known as internal radiation, is another way to deliver radiation therapy. Instead of aiming radiation beams from outside the body, a device containing radioactive seeds or pellets is placed inside the body, near the cancer. This is not commonly done for ovarian cancer.

More information about radiation therapy

To learn more about how radiation is used to treat cancer, see Radiation Therapy.

To learn about some of the side effects listed here and how to manage them, see Managing Cancer-related Side Effects.

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Developed by the ÁñÁ«ÊÓÆµ medical and editorial content team with medical review and contribution by the American Society of Clinical Oncology (ASCO).

Cannistra SA, Gershenson DM, Recht A. Ch 76 - Ovarian cancer, fallopian tube carcinoma, and peritoneal carcinoma. In: DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: Principles and Practice of Oncology. 10th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2015.

Morgan M, Boyd J, Drapkin R, Seiden MV. Ch 89 ¨C Cancers Arising in the Ovary. In: Abeloff MD, Armitage JO, Lichter AS, Niederhuber JE, Kastan MB, McKenna WG, eds. Clinical Oncology. 5th ed. Philadelphia, PA: Elsevier; 2014: 1592.

National Comprehensive Cancer Network (NCCN)--Ovarian Cancer Including Fallopian Tube Cancer and Primary Peritoneal Cancer. V2.2025. Accessed May 20, 2025 from https://www.nccn.org/professionals/physician_gls/pdf/ovarian.pdf

Last Revised: August 8, 2025

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